Myostatin, also known as growth differentiation factor 8, a member of the transforming
growth factor‐beta super‐family, is a negative regulator of muscle development. Myostatin …

Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β
family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by …

Intense selective pressures applied over short evolutionary time have resulted in
homogeneity within, but substantial variation among, horse breeds. Utilizing this population …

Myostatin inhibition therapy has held much promise for the treatment of muscle wasting
disorders. This is particularly true for the fatal myopathy, Duchenne Muscular Dystrophy …

Animal domestication is considered a complex and multistage process that altered
behaviorally, morphologically, and physiologically the domesticates relative to their wild …

Selective breeding for speed in the racehorse has resulted in an unusually high frequency of
the C-variant (g. 66493737C/T) at the myostatin gene (MSTN) in cohorts of the …

Thoroughbred horses are finely-tuned athletes with a high aerobic capacity relative to
skeletal muscle mass, attributable to centuries of genetic selection for speed and stamina …

Myostatin (MSTN) is one of the key factors regulating myogenesis. Because of its role as a
negative regulator of muscle mass deposition, much interest has been given to its protein …

Myostatin is a member of the transforming growth factor-β family with a key role in inhibition
of muscle growth by negative regulation of both myoblast proliferation and differentiation …

Background Hypoxaemia is a common concern during equine general anaesthesia. The
prevalence and predictors of hypoxaemia in horses undergoing elective anaesthesia in …