Simple Summary Ovarian high-grade serous carcinoma (HGSC) has a 5-year survival rate
of less than 50%, making it one of the most lethal gynecological cancers for women in the …

Background There is a high unmet need for treatment regimens that increase the chance of
long-term remission and possibly cure for women with newly diagnosed advanced ovarian …

Ovarian cancer (OC) represents the main cause of death from gynecological malignancies
in western countries. Altered cellular and mitochondrial metabolism are considered …

High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to
the limited effectiveness of existing chemo-and immunotherapies. To elucidate mechanisms …

Background High-grade serous ovarian cancer (HGSOC) has poor survival rates due to a
combination of diagnosis at advanced stage and disease recurrence as a result of …

Vaginal cancer is a rare and uncommon disease that is rarely discussed. Although vaginal
cancer traditionally occurs in older postmenopausal women, the incidence of high-risk …

Two related tumor suppressor genes, BRCA1 and BRCA2, attract a lot of attention from both
fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are …

Ovarian carcinoma remains the most lethal gynaecologic malignancy. Half of all high-grade
serous ovarian cancers (HGSOCs) have a homologous recombination deficiency (HRD) …

High-grade serous carcinoma (HGSCa) of the ovary is featured by TP53 gene mutation.
Missense or nonsense mutation types accompany most cases of HGSCa that correlate well …

BRCA1 and BRCA2 are multi-functional proteins and key factors for maintaining genomic
stability through their roles in DNA double strand break repair by homologous …