[HTML][HTML] Current and emerging methods for ovarian cancer screening and diagnostics: a comprehensive review
Simple Summary Ovarian high-grade serous carcinoma (HGSC) has a 5-year survival rate
of less than 50%, making it one of the most lethal gynecological cancers for women in the …
of less than 50%, making it one of the most lethal gynecological cancers for women in the …
Maintenance olaparib for patients with newly diagnosed advanced ovarian cancer and a BRCA mutation (SOLO1/GOG 3004): 5-year follow-up of a randomised …
S Banerjee, KN Moore, N Colombo, G Scambia… - The Lancet …, 2021 - thelancet.com
Background There is a high unmet need for treatment regimens that increase the chance of
long-term remission and possibly cure for women with newly diagnosed advanced ovarian …
long-term remission and possibly cure for women with newly diagnosed advanced ovarian …
[HTML][HTML] Ovarian cancer: a landscape of mitochondria with emphasis on mitochondrial dynamics
D De Rasmo, A Cormio, G Cormio… - International Journal of …, 2023 - mdpi.com
Ovarian cancer (OC) represents the main cause of death from gynecological malignancies
in western countries. Altered cellular and mitochondrial metabolism are considered …
in western countries. Altered cellular and mitochondrial metabolism are considered …
Senescence induction dictates response to chemo-and immunotherapy in preclinical models of ovarian cancer
SV Paffenholz, C Salvagno, YJ Ho… - Proceedings of the …, 2022 - National Acad Sciences
High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to
the limited effectiveness of existing chemo-and immunotherapies. To elucidate mechanisms …
the limited effectiveness of existing chemo-and immunotherapies. To elucidate mechanisms …
[HTML][HTML] Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients
M Buttarelli, A Ciucci, F Palluzzi, G Raspaglio… - Journal of Experimental …, 2022 - Springer
Background High-grade serous ovarian cancer (HGSOC) has poor survival rates due to a
combination of diagnosis at advanced stage and disease recurrence as a result of …
combination of diagnosis at advanced stage and disease recurrence as a result of …
[HTML][HTML] A comprehensive discussion in vaginal cancer based on mechanisms, treatments, risk factors and prevention
Vaginal cancer is a rare and uncommon disease that is rarely discussed. Although vaginal
cancer traditionally occurs in older postmenopausal women, the incidence of high-risk …
cancer traditionally occurs in older postmenopausal women, the incidence of high-risk …
[HTML][HTML] BRCA mutations—the Achilles heel of breast, ovarian and other epithelial cancers
AP Loboda, LS Adonin, SD Zvereva… - International journal of …, 2023 - mdpi.com
Two related tumor suppressor genes, BRCA1 and BRCA2, attract a lot of attention from both
fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are …
fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are …
[HTML][HTML] Impact of Molecular Testing on the Surgical Management of Advanced Epithelial Ovarian Cancer
PE Colombo, C Taoum, M Fabbro, S Quesada… - Critical Reviews in …, 2024 - Elsevier
Ovarian carcinoma remains the most lethal gynaecologic malignancy. Half of all high-grade
serous ovarian cancers (HGSOCs) have a homologous recombination deficiency (HRD) …
serous ovarian cancers (HGSOCs) have a homologous recombination deficiency (HRD) …
[HTML][HTML] p53 immunohistochemistry and mutation types mismatching in high-grade serous ovarian cancer
E Park, H Han, SE Choi, H Park, HY Woo, M Jang… - Diagnostics, 2022 - mdpi.com
High-grade serous carcinoma (HGSCa) of the ovary is featured by TP53 gene mutation.
Missense or nonsense mutation types accompany most cases of HGSCa that correlate well …
Missense or nonsense mutation types accompany most cases of HGSCa that correlate well …
Lessons learned from understanding chemotherapy resistance in epithelial tubo-ovarian carcinoma from BRCA1and BRCA2mutation carriers
BRCA1 and BRCA2 are multi-functional proteins and key factors for maintaining genomic
stability through their roles in DNA double strand break repair by homologous …
stability through their roles in DNA double strand break repair by homologous …