Sarcoplasmic reticulum: the dynamic calcium governor of muscle

AE Rossi, RT Dirksen - Muscle & Nerve: Official Journal of the …, 2006 - Wiley Online Library
The sarcoplasmic reticulum (SR) provides feedback control required to balance the
processes of calcium storage, release, and reuptake in skeletal muscle. This balance is …

Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies

CH George, H Jundi, NL Thomas, DL Fry… - Journal of molecular and …, 2007 - Elsevier
It has been six years since the first reported link between mutations in the cardiac ryanodine
receptor Ca2+ release channel (RyR2) and catecholaminergic polymorphic ventricular …

PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth

GA Wayman, DD Bose, D Yang, A Lesiak… - Environmental …, 2012 - ehp.niehs.nih.gov
Background: Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) promote dendritic
growth in hippocampal neurons via ryanodine receptor (RyR)-dependent mechanisms; …

Preclinical model systems of ryanodine receptor 1-related myopathies and malignant hyperthermia: a comprehensive scoping review of works published 1990–2019

TA Lawal, ES Wires, NL Terry, JJ Dowling… - Orphanet journal of rare …, 2020 - Springer
Background Pathogenic variations in the gene encoding the skeletal muscle ryanodine
receptor (RyR1) are associated with malignant hyperthermia (MH) susceptibility, a life …

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains

CH George, H Jundi, NL Thomas… - Molecular biology of …, 2004 - Am Soc Cell Biol
Ryanodine receptors (RyR) function as Ca2+ channels that regulate Ca2+ release from
intracellular stores to control a diverse array of cellular processes. The massive cytoplasmic …

A Ca2+-binding domain in RyR1 that interacts with the calmodulin binding site and modulates channel activity

L Xiong, JZ Zhang, R He, SL Hamilton - Biophysical journal, 2006 - cell.com
A fragment of RyR1 (amino acids 4064–4210) is predicted to fold to at least one lobe of
calmodulin and to bind Ca 2+. This fragment of RyR1 (R4064–4210) was subcloned …

Novel types of Ca2+ release channels participate in the secretory cycle of Paramecium cells

EM Ladenburger, IM Sehring, I Korn… - Molecular and cellular …, 2009 - Am Soc Microbiol
A database search of the Paramecium genome reveals 34 genes related to Ca 2+-release
channels of the inositol-1, 4, 5-trisphosphate (IP 3) or ryanodine receptor type (IP 3 R, RyR) …

Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle

CF Perez, JR López, PD Allen - American Journal of …, 2005 - journals.physiology.org
To better understand the role of the transient expression of ryanodine receptor (RyR) type 3
(RyR3) on Ca2+ homeostasis during the development of skeletal muscle, we have analyzed …

Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1

JD Fessenden, W Feng, IN Pessah, PD Allen - Journal of Biological …, 2004 - ASBMB
The functional relevance of putative Ca 2+ binding motifs previously identified with Ca 2+
overlay binding analysis within the skeletal muscle ryanodine receptor isoform (RyR1) was …

Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes

AHY Lin, H Sun, O Paudel, MJ Lin… - Cardiovascular …, 2016 - academic.oup.com
Abstract Aims Store-operated Ca2+ entry (SOCE) contributes to a multitude of physiological
and pathophysiological functions in pulmonary vasculatures. SOCE attributable to inositol 1 …