Inhibition of protein misfolding and aggregation by natural phenolic compounds

Z Dhouafli, K Cuanalo-Contreras, EA Hayouni… - Cellular and molecular …, 2018 - Springer
Protein misfolding and aggregation into fibrillar deposits is a common feature of a large
group of degenerative diseases affecting the central nervous system or peripheral organs …

[HTML][HTML] Therapeutic potential of phytoconstituents in management of Alzheimer's disease

AK Singh, SN Rai, A Maurya, G Mishra… - Evidence-based …, 2021 - hindawi.com
Since primitive times, herbs have been extensively used in conventional remedies for
boosting cognitive impairment and age-associated memory loss. It is mentioned that …

Studies on the inhibition of α-glucosidase by biflavonoids and their interaction mechanisms

H Li, J Yang, M Wang, X Ma, X Peng - Food Chemistry, 2023 - Elsevier
Biflavonoids are a kind of polyphenol compounds with numerous biological functions.
However, the potential inhibitory activities of biflavonoids on α-glucosidase are yet unknown …

Curcumin attenuates amyloid-β aggregate toxicity and modulates amyloid-β aggregation pathway

A Thapa, SD Jett, EY Chi - ACS chemical neuroscience, 2016 - ACS Publications
The abnormal misfolding and aggregation of amyloid-β (Aβ) peptides into β-sheet enriched
insoluble deposits initiates a cascade of events leading to pathological processes and …

The multifunctional roles of flavonoids against the formation of advanced glycation end products (AGEs) and AGEs-induced harmful effects

Q Zhou, KW Cheng, J Xiao, M Wang - Trends in Food Science & …, 2020 - Elsevier
Background Advanced glycation end products (AGEs) play a crucial role in the onset,
progression, and propagation of both macroangiopathy and microangiopathy complications …

Emerging signal regulating potential of small molecule biflavonoids to combat neuropathological insults of Alzheimer's disease

MS Uddin, MT Kabir, D Tewari, B Mathew… - Science of the Total …, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive, chronic and severe neurodegenerative disorder
linked with cognitive and memory impairment that eventually lead to death. There are …

Dietary modulation of oxidative stress in Alzheimer's disease

A Thapa, NJ Carroll - International journal of molecular sciences, 2017 - mdpi.com
Cells generate unpaired electrons, typically via oxygen-or nitrogen-based by-products
during normal cellular respiration and under stressed situations. These pro-oxidant …

Impact of plant-derived flavonoids on neurodegenerative diseases

SL Costa, VDA Silva, C dos Santos Souza… - Neurotoxicity …, 2016 - Springer
Neurodegenerative disorders have a common characteristic that is the involvement of
different cell types, typically the reactivity of astrocytes and microglia, characterizing gliosis …

Structural analysis of flavonoids and related compounds-a review of spectroscopic applications

PF Pinheiro, GC Justino - … —A Global Perspective of Their Role in …, 2012 - books.google.com
In 1936 St. Rusznyák and A. Szent-Györgyi described, in a paper in Nature (Rusznyàk &
Szent-György, 1936), the relief of certain pathological conditions, characterized by an …

Proceedings of chemistry, pharmacology, pharmacokinetics and synthesis of biflavonoids

X He, F Yang, X Huang - Molecules, 2021 - mdpi.com
Biflavonoids, composed of two monoflavonoid residues, occur naturally in angiosperms,
bryophytes, ferns, and gymnosperms. More than 592 biflavonoids have been structurally …