Investigation of macromolecular structure and dynamics is fundamental to understanding
how macromolecules carry out their functions in the cell. Significant advances have been …

Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for studying the
structure and dynamics of proteins in their native state. For high-resolution NMR structure …

Chemical cross-linking combined with mass spectrometry has proven useful for studying
protein-protein interactions and protein structure, however the low density of cross-link data …

Many neurodegenerative diseases are characterized by misfolding and aggregation of an
expanded polyglutamine tract (polyQ). Huntington's Disease, caused by expansion of the …

Pathogenic fungal diseases in crops are mediated by the release of effector proteins that
facilitate infection. Characterising the structure of these fungal effectors is vital to …

The combination of deep learning and sequence data has transformed protein structure
prediction and modeling, evidenced in the success of AlphaFold (AF). For this reason, many …

Voltage-dependent anion channel (VDAC), the major channel of the mitochondrial outer
membrane, serves as a principal pathway for ATP, ADP, and other respiratory substrates …

Public protein sequence databases contain samples from the fitness landscape explored by
nature. Protein language models (pLMs) pre-trained on these sequences aim to capture this …

Deregulation of the von Hippel-Lindau tumor suppressor protein (pVHL) is considered one
of the main causes for malignant renal clear-cell carcinoma (ccRCC) insurgence. In human …

As recognition of the abundance and relevance of intrinsically disordered proteins (IDPs)
continues to grow, demand increases for methods that can rapidly predict the conformational …