Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …

The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid
receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are …

The obesity pandemic increasingly causes morbidity and mortality from type 2 diabetes,
cardiovascular diseases and many other chronic diseases. Fat cell size (FCS) predicts …

During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

Overnutrition causes obesity, a global health problem without any effective therapy. Obesity
is characterized by low-grade inflammation, which predisposes individuals to metabolic …

The androgen receptor (AR) is overexpressed and hyperactivated in human castration-
resistant prostate cancer (CRPC). However, the determinants of AR overexpression in …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin
remains controversial. ROR is inextricably linked to melatonin in terms of its expression …

The retinoic-acid-receptor-related orphan receptors (RORs) are members of the nuclear
receptor (NR) superfamily whose activity has been implicated in several physiological and …