All-optical interrogation of neural circuits in behaving mice
Recent advances combining two-photon calcium imaging and two-photon optogenetics with
computer-generated holography now allow us to read and write the activity of large …
computer-generated holography now allow us to read and write the activity of large …
Monitoring activity in neural circuits with genetically encoded indicators
Recent developments in genetically encoded indicators of neural activity (GINAs) have
greatly advanced the field of systems neuroscience. As they are encoded by DNA, GINAs …
greatly advanced the field of systems neuroscience. As they are encoded by DNA, GINAs …
[HTML][HTML] Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance
L Madisen, AR Garner, D Shimaoka, AS Chuong… - Neuron, 2015 - cell.com
An increasingly powerful approach for studying brain circuits relies on targeting genetically
encoded sensors and effectors to specific cell types. However, current approaches for this …
encoded sensors and effectors to specific cell types. However, current approaches for this …
Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism
T Sato, MG Shapiro, DY Tsao - Neuron, 2018 - cell.com
Ultrasound has received widespread attention as an emerging technology for targeted, non-
invasive neuromodulation based on its ability to evoke electrophysiological and motor …
invasive neuromodulation based on its ability to evoke electrophysiological and motor …
Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons
Brain hemodynamics serve as a proxy for neural activity in a range of noninvasive
neuroimaging techniques including functional magnetic resonance imaging (fMRI). In …
neuroimaging techniques including functional magnetic resonance imaging (fMRI). In …
Network-level control of frequency tuning in auditory cortex
HK Kato, SK Asinof, JS Isaacson - Neuron, 2017 - cell.com
Lateral inhibition is a fundamental circuit operation that sharpens the tuning properties of
cortical neurons. This operation is classically attributed to an increase in GABAergic synaptic …
cortical neurons. This operation is classically attributed to an increase in GABAergic synaptic …
Flexible sensory representations in auditory cortex driven by behavioral relevance
Animals require the ability to ignore sensory stimuli that have no consequence yet respond
to the same stimuli when they become useful. However, the brain circuits that govern this …
to the same stimuli when they become useful. However, the brain circuits that govern this …
The mouse cortical connectome, characterized by an ultra-dense cortical graph, maintains specificity by distinct connectivity profiles
The inter-areal wiring pattern of the mouse cerebral cortex was analyzed in relation to a
refined parcellation of cortical areas. Twenty-seven retrograde tracer injections were made …
refined parcellation of cortical areas. Twenty-seven retrograde tracer injections were made …
Large-scale imaging of cortical dynamics during sensory perception and behavior
JB Wekselblatt, ED Flister… - Journal of …, 2016 - journals.physiology.org
Sensory-driven behaviors engage a cascade of cortical regions to process sensory input
and generate motor output. To investigate the temporal dynamics of neural activity at this …
and generate motor output. To investigate the temporal dynamics of neural activity at this …
Homeostatic control of spontaneous activity in the developing auditory system
Neurons in the developing auditory system exhibit spontaneous bursts of activity before
hearing onset. How this intrinsically generated activity influences development remains …
hearing onset. How this intrinsically generated activity influences development remains …