Infectious diseases, along with cancers, are among the main causes of death among
humans worldwide. The production of therapeutic proteins for treating diseases at large …

Introduction: The development of novel complex biotherapeutics led to new challenges in
biopharmaceutical industry. The potential of these particles has been demonstrated by the …

Membrane systems play an essential role in the production of all biopharmaceuticals. This
includes initial clarification of cell culture fluid by both depth filtration and tangential flow …

The recent success of mRNA vaccines has generated increased interest in the use of Lipid
Nanoparticles (LNPs) for delivery of nucleic acids. The objective of this study was to …

Implants and prostheses are widely used to replace damaged tissues or to treat various
diseases. However, besides the risk of bacterial or fungal infection, an inflammatory …

In the midst of the ongoing COVID-19 coronavirus pandemic, influenza virus remains a
major threat to public health due to its potential to cause epidemics and pandemics with …

Downstream processing (DSP) of large bionanoparticles is still a challenge. The present
study aims to systematically compare some of the most commonly used DSP strategies for …

Virus-like particles (VLPs) are emerging nanoscale protein assemblies applied as
prophylactic vaccines and in development as therapeutic vaccines or cargo delivery …

With technological advancements enabling globalization, the intercontinental transmission
of pathogens has become much easier. Respiratory viruses are one such group of …

Virus‐like particles‐based vaccines have been gaining interest in recent years. The
manufacturing of these particles includes their production by cell culture followed by their …