Myocardial and vascular endothelial tissues have receptors for thyroid hormones and are
sensitive to changes in the concentrations of circulating thyroid hormones. The importance …

The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …

Thyroid hormone has many effects on the heart and vascular system. 1 Many of the clinical
manifestations of hyperthyroidism are due to the ability of thyroid hormone to alter …

Thyroid hormones have long been known to have a range of effects on the cardiovascular
system. However, significant knowledge gaps exist concerning the precise molecular and …

The cardiovascular signs and symptoms of thyroid disease are some of the most profound
and clinically relevant findings that accompany both hyperthyroidism and hypothyroidism …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

The heart is a major target organ for thyroid hormone action, and marked changes occur in
cardiac function in patients with hypo-or hyperthyroidism. T3-induced changes in cardiac …

The sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA) is a pump that
transports calcium ions from the cytoplasm into the SR. It is present in both animal and plant …

Increased or reduced action of thyroid hormone on certain molecular pathways in the heart
and vasculature causes relevant cardiovascular derangements. It is well established that …

Simmerman, Heather KB, and Larry R. Jones. Phospholamban: Protein Structure,
Mechanism of Action, and Role in Cardiac Function. Physiol. Rev. 78: 921–947, 1998.—A …