Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

BACKGROUND Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and
heterogeneous endocrine disorder in women of reproductive age. Although patients with …

Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of
what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular …

Understanding the physiology underlying the complex dialog between the oocyte and its
surrounding somatic cells within the ovarian follicle has been crucial in defining optimal …

The formation of tissue produced by implanted cells is influenced greatly by the scaffold onto
which they are seeded. In the long term it is often preferable to use a biodegradable material …

The TGF-β superfamily is the largest family of secreted proteins in mammals, and members
of the TGF-β family are involved in most developmental and physiological processes …

BACKGROUND A large number of studies have contributed to understanding the general
mechanisms driving ovarian folliculogenesis in humans and show a complex endocrine …

Proper physiological function of the ovaries is very important for the entire female
reproductive system and overall health. Reactive oxygen species (ROS) are generated as …

Cumulus cell–oocyte communication is an essential feature of mammalian reproduction.
Established mechanisms involve the bidirectional transfer of ions and small molecules …