Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …

When secreted into the circulation, proprotein convertase subtilisin kexin type 9 (PCSK9)
blocks the low-density lipoprotein receptors (LDL-R) and, as a consequence, low-density …

Abstract Lipoprotein (a)[Lp (a)] is a well-recognized, independent risk factor for
atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in …

Background Elevated lipoprotein (a) is a genetic risk factor for cardiovascular disease in
general population studies. However, its contribution to risk for cardiovascular events in …

Genome-wide association studies have identified numerous loci linked with complex
diseases, for which the molecular mechanisms remain largely unclear. Comprehensive …

We conducted a genome-wide association analysis of 7 subfractions of low density
lipoproteins (LDLs) and 3 subfractions of intermediate density lipoproteins (IDLs) measured …

Statins effectively lower LDL cholesterol levels in large studies and the observed
interindividual response variability may be partially explained by genetic variation. Here we …

Lipoprotein (a)[Lp (a)] is an independent risk factor for cardiovascular disease, with limited
treatment options. This analysis evaluated the effect of a monoclonal antibody to proprotein …

Background and aims Many patients treated with statins are considered statin-resistant
because they fail to achieve adequate reduction of low density lipoprotein cholesterol (LDL …

The increasing availability of genotype data linked with information about drug‐response
phenotypes has enabled genomewide association studies (GWAS) that uncover genetic …