Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

Metabolic diseases are often characterized by circadian misalignment in different tissues,
yet how altered coordination and communication among tissue clocks relate to specific …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

The central nervous system (CNS) has an important role in the regulation of peripheral
insulin sensitivity and glucose homeostasis. Research in this dynamically developing field …

The discovery of brown adipose tissue (BAT) in adult humans presents a new therapeutic
target for metabolic disease; however, little is known about the regulation of human BAT …

All biological processes, living organisms, and ecosystems have evolved with the Sun that
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …

Obesity is a major risk factor for the development of illnesses, such as insulin resistance and
hypertension, and has become a serious public health problem. Mammals have developed …

Purpose Brown adipose tissue (BAT) activation in humans has gained interest as a potential
target for treatment of obesity and insulin resistance. In rodents, BAT is primarily induced …