Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Chronic inflammation plays an important role in the development of metabolic diseases.
These include obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated fatty …

Continuous proliferation of tumor cells requires constant adaptations of energy metabolism
to rapidly fuel cell growth and division. This energetic adaptation often comprises …

Cancer cells face various metabolic challenges during tumor progression, including growth
in the nutrient-altered and oxygen-deficient microenvironment of the primary site …

Cancer is characterized by metabolic reprogramming, which is a hot topic in tumor treatment
research. Cancer cells alter metabolic pathways to promote their growth, and the common …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Besides fast glucose catabolism, many types of cancers are characterized by elevated
glutamine consumption. Medical oncology pursuits to block specific pathways, mainly …

Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …