Although many studies have demonstrated that components of the hemostatic system may
be involved in signaling leading to cancer progression, the potential mechanisms by which …

TGF-β has a dual role in tumorigenesis, acting as a tumor suppressor in normal cells and in
the early stages of tumor development while promoting carcinogenesis and metastasis in …

Background Previous studies have established that proteinase-activated receptor 2 (PAR 2)
promotes migration and invasion of hepatocellular carcinoma (HCC) cells, suggesting a role …

Abstract Protease-activated receptor 2 (PAR2) is a member of G-protein coupled receptors,
which is widely expressed in intestinal epithelium and immune cells and plays critical roles …

It has been 30 years since the first member of the protease-activated receptor (PAR) family
was discovered. This was followed by the discovery of three other receptors, including …

The G protein-coupled receptor proteinase-activated receptor 2 (PAR2) has been implicated
in various aspects of cellular physiology including inflammation, obesity and cancer. In …

Cancer‐associated fibroblasts (CAFs) are known to contribute to cancer progression. We
have reported that cell surface expression of hepatocyte growth factor activator inhibitor 1 …

The currently used anti-cancer therapies work by killing cancer cells but result in adverse
effects and resistance to treatment, which accelerates aging and causes damage to normal …

The maintenance and expansion of cancer stem-like cells (CSCs) is necessary for
metastasis. Although protease-activated receptor 2 (PAR2) is strongly associated with …

Abstract Protease-activated receptor 2 (PAR-2) has been demonstrated to promote invasion
and metastasis of certain cancer cells. This study aimed to investigate the mechanism by …