The cellular complexity of the human brain is established via dynamic changes in gene
expression throughout development that is mediated, in part, by the spatiotemporal activity …

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized
by social deficits, repetitive behaviours and lack of empathy. Its significant genetic heritability …

To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …

The synovium is an important component of any synovial joint and is the major target tissue
of inflammatory arthritis. However, the multi-omics landscape of synovium required for …

Stroke, characterized by sudden neurological deficits, is the second leading cause of death
worldwide. Although genome-wide association studies (GWAS) have successfully identified …

Chromatin architecture regulates gene expression and shapes cellular identity, particularly
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …

Background Sex differences in the brain may play an important role in sex-differential
prevalence of neuropsychiatric conditions. Methods In order to understand the …

Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA
modification within the brain. Yet, most research has relied on postmortem samples …

Enhancers play an essential role in the etiology of schizophrenia; however, the
dysregulation of enhancer activity and its impact on the regulome in schizophrenia remains …

Non-coding variants increase risk of neuropsychiatric disease. However, our understanding
of the cell-type specific role of the non-coding genome in disease is incomplete. We …