Multi-omic profiling of the developing human cerebral cortex at the single-cell level
The cellular complexity of the human brain is established via dynamic changes in gene
expression throughout development that is mediated, in part, by the spatiotemporal activity …
expression throughout development that is mediated, in part, by the spatiotemporal activity …
Towards understanding sex differences in autism spectrum disorders
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized
by social deficits, repetitive behaviours and lack of empathy. Its significant genetic heritability …
by social deficits, repetitive behaviours and lack of empathy. Its significant genetic heritability …
The three-dimensional landscape of cortical chromatin accessibility in Alzheimer's disease
To characterize the dysregulation of chromatin accessibility in Alzheimer's disease (AD), we
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
generated 636 ATAC-seq libraries from neuronal and nonneuronal nuclei isolated from the …
A landscape of gene expression regulation for synovium in arthritis
F Jiang, SY Hu, W Tian, NN Wang, N Yang… - Nature …, 2024 - nature.com
The synovium is an important component of any synovial joint and is the major target tissue
of inflammatory arthritis. However, the multi-omics landscape of synovium required for …
of inflammatory arthritis. However, the multi-omics landscape of synovium required for …
Novel insight into the etiology of ischemic stroke gained by integrative multiome-wide association study
Stroke, characterized by sudden neurological deficits, is the second leading cause of death
worldwide. Although genome-wide association studies (GWAS) have successfully identified …
worldwide. Although genome-wide association studies (GWAS) have successfully identified …
Extensive long-range polycomb interactions and weak compartmentalization are hallmarks of human neuronal 3D genome
IA Pletenev, M Bazarevich, DR Zagirova… - Nucleic Acids …, 2024 - academic.oup.com
Chromatin architecture regulates gene expression and shapes cellular identity, particularly
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease
Background Sex differences in the brain may play an important role in sex-differential
prevalence of neuropsychiatric conditions. Methods In order to understand the …
prevalence of neuropsychiatric conditions. Methods In order to understand the …
[HTML][HTML] Divergent landscapes of A-to-I editing in postmortem and living human brain
M Rodriguez de los Santos, BH Kopell… - nature …, 2024 - nature.com
Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA
modification within the brain. Yet, most research has relied on postmortem samples …
modification within the brain. Yet, most research has relied on postmortem samples …
Convergence of the dysregulated regulome in schizophrenia with polygenic risk and evolutionarily constrained enhancers
Enhancers play an essential role in the etiology of schizophrenia; however, the
dysregulation of enhancer activity and its impact on the regulome in schizophrenia remains …
dysregulation of enhancer activity and its impact on the regulome in schizophrenia remains …
[HTML][HTML] The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development
Non-coding variants increase risk of neuropsychiatric disease. However, our understanding
of the cell-type specific role of the non-coding genome in disease is incomplete. We …
of the cell-type specific role of the non-coding genome in disease is incomplete. We …