The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

The intestinal epithelium acts as a key defensive barrier that protects internal organs from
the detrimental gut environment. The homeostasis of the gut epithelium may be altered by …

Limited experimental evidence bridges nutrition and cancer immunosurveillance. Here, we
show that ketogenic diet (KD)—or its principal ketone body, 3-hydroxybutyrate (3HB), most …

Background: Recent studies had explored that gut microbiota was associated with
neurodegenerative diseases (including Alzheimer's disease (AD), Parkinson's disease (PD) …

The gut microbiota plays an important role in neurological diseases via the gut–brain axis.
Many factors such as diet, antibiotic therapy, stress, metabolism, age, geography and …

Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are
involved in human developmental disorders and ALS. Here we show that NEK1 regulates …

Alzheimer's disease (AD) and cancer have much in common than previously recognized.
These pathologies share common risk factors (inflammation and aging), with similar …

Dietary intervention is widely used as a therapeutic approach ranging from the treatment of
neurological disorders to attempts to extend lifespan. The most important effect of various …

Immunotherapy based on programmed cell death protein-1 (PD-1) is a promising approach
in oncology. However, a significant fraction of patients remain unresponsive. Therefore, it is …

Lowered high-density lipoprotein (HDL) cholesterol has been reported in major depressive
disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major …