Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …
regimen that mimics the metabolism of the fasting state to induce the production of ketone …
Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases
The intestinal epithelium acts as a key defensive barrier that protects internal organs from
the detrimental gut environment. The homeostasis of the gut epithelium may be altered by …
the detrimental gut environment. The homeostasis of the gut epithelium may be altered by …
[HTML][HTML] Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade
Limited experimental evidence bridges nutrition and cancer immunosurveillance. Here, we
show that ketogenic diet (KD)—or its principal ketone body, 3-hydroxybutyrate (3HB), most …
show that ketogenic diet (KD)—or its principal ketone body, 3-hydroxybutyrate (3HB), most …
Investigating casual associations among gut microbiota, metabolites, and neurodegenerative diseases: a Mendelian randomization study
J Ning, SY Huang, SD Chen, YR Zhang… - Journal of …, 2022 - content.iospress.com
Background: Recent studies had explored that gut microbiota was associated with
neurodegenerative diseases (including Alzheimer's disease (AD), Parkinson's disease (PD) …
neurodegenerative diseases (including Alzheimer's disease (AD), Parkinson's disease (PD) …
A review on preventive role of ketogenic diet (KD) in CNS disorders from the gut microbiota perspective
The gut microbiota plays an important role in neurological diseases via the gut–brain axis.
Many factors such as diet, antibiotic therapy, stress, metabolism, age, geography and …
Many factors such as diet, antibiotic therapy, stress, metabolism, age, geography and …
NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are
involved in human developmental disorders and ALS. Here we show that NEK1 regulates …
involved in human developmental disorders and ALS. Here we show that NEK1 regulates …
Cancer and Alzheimer's disease: intracellular pH scales the metabolic disorders
Alzheimer's disease (AD) and cancer have much in common than previously recognized.
These pathologies share common risk factors (inflammation and aging), with similar …
These pathologies share common risk factors (inflammation and aging), with similar …
Effects of ketogenic diet on muscle metabolism in health and disease
EI Yakupova, AD Bocharnikov, EY Plotnikov - Nutrients, 2022 - mdpi.com
Dietary intervention is widely used as a therapeutic approach ranging from the treatment of
neurological disorders to attempts to extend lifespan. The most important effect of various …
neurological disorders to attempts to extend lifespan. The most important effect of various …
Mitochondria determine response to anti-programmed cell death protein-1 (anti-PD-1) immunotherapy: An evidence-based hypothesis
Immunotherapy based on programmed cell death protein-1 (PD-1) is a promising approach
in oncology. However, a significant fraction of patients remain unresponsive. Therefore, it is …
in oncology. However, a significant fraction of patients remain unresponsive. Therefore, it is …
The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders
G Morris, BK Puri, CC Bortolasci, A Carvalho… - Neuroscience & …, 2021 - Elsevier
Lowered high-density lipoprotein (HDL) cholesterol has been reported in major depressive
disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major …
disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major …