Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic
with potential antiaging and antidiabetogenic properties. It is widely consumed as a …

Phospholipase C (PLC) converts phosphatidylinositol 4, 5-bisphosphate (PIP2) to inositol 1,
4, 5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

The pulmonary endothelium is a dynamic, metabolically active layer of squamous
endothelial cells ideally placed to mediate key processes involved in lung homoeostasis …

The hydrolysis of ATP drives virtually all of the energy-requiring processes in living cells. A
prerequisite of living cells is that the concentration of ATP needs to be maintained at …

Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

The endothelium is a semi‐permeable barrier that regulates the flux of liquid and solutes,
including plasma proteins, between the blood and surrounding tissue. The permeability of …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …