Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

Homologous recombination is a fundamental biological process. Biochemical
understanding of this process is most advanced for Escherichia coli. At least 25 gene …

Abstract The 3.3-Å resolution crystal structure of the large proteolytic fragment of Escherichia
coli DNA polymerase I complexed with deoxythymidine monophosphate consists of two …

SEQUENCE ALIGNMENT The multiple alignments ofthe amino acid sequences for this
update were performed in most cases by merely adding on to our original alignments (1) …

We reported elsewhere (Varenne et al., 1982) that, during synthesis of a number of colicins
in Escherichia coli, intermediate nascent chains of discrete sizes accumulated, suggesting a …

Specific binding of dnaA protein to the E. coli origin of replication (ore) is essential for
initiation of chromosomal replication. Based on binding of plasmid DNA fragments, dnaA …

Summary The 3'~ 5'exonuclease active site of E. coli DNA polymerase I is predicted to be
conserved for both prokaryotic and eukaryotic DNA polymerases based on amino acid …

E. coli DNA polymerase IH is a multisubunit enzyme encoded by various dna genes (55); the
DNA polymerizing a-subunit encoded by thepolC (dnaE) gene (56) and the 3' …

In infected cells, the RNA genomes of RNA tumour viruses are copied into DNA by a virus-
encoded reverse transcriptase enzyme1–3. This transfer of information from RNA into DNA …

We have used site‐directed mutagenesis to change amino acid side chains that have been
shown crystallographically to be in close proximity to a DNA 3′ terminus bound at the 3 …