X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …

Mouse epiblast stem cells (EpiSCs) can be derived from a wide range of developmental
stages. To characterize and compare EpiSCs with different origins, we derived a series of …

Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle
through a state characterized by decondensed chromatin and expression of transcripts …

The importance of maternal folate consumption for normal development is well established,
yet the molecular mechanism linking folate metabolism to development remains poorly …

Background Selective maintenance of genomic epigenetic imprints during pre-implantation
development is required for parental origin-specific expression of imprinted genes. The …

The defining features of embryonic stem cells (ESCs) are their self-renewing and pluripotent
capacities. Indeed, the ability to give rise into all cell types within the organism not only …

Genome editing occurs in the context of chromatin, which is heterogeneous in structure and
function across the genome. Chromatin heterogeneity is thought to affect genome editing …

In diploid organisms, biallelic gene expression enables the production of adequate levels of
mRNA,. This is essential for haploinsufficient genes, which require biallelic expression for …

Mammalian parental imprinting represents an exquisite form of epigenetic control regulating
the parent-specific monoallelic expression of genes in clusters. While imprinting …