The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Cell therapies for neurological disorders are entering the clinic and present unique
challenges and opportunities compared with conventional medicines. They have the …

The specific loss of midbrain dopamine neurons (mDANs) causes major motor dysfunction
in Parkinson's disease, which makes cell replacement a promising therapeutic approach …

Hematopoietic cell transplantation after myeloablative conditioning has been used to treat
various genetic metabolic syndromes but is largely ineffective in diseases affecting the brain …

This paper builds on the context and recent progress on the control, reproducibility, and
limitations of using graphene and graphene-related materials (GRMs) in biomedical …

Cellular therapies are poised to transform the field of medicine by restoring dysfunctional
tissues and treating various diseases in a dynamic manner not achievable by conventional …

Neurotrophic factors (NTFs) are small secreted proteins that support the development,
maturation and survival of neurons. NTFs injected into the brain rescue and regenerate …

Rationale: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is
characterized by degeneration of dopaminergic neurons (DA) at the substantia nigra pas …

Parkinson's disease (PD) is currently the fastest growing disabling neurological disorder
worldwide, with motor and non-motor symptoms being its main clinical manifestations. The …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, affecting 1%–2% of the population over the age of 65. As the …