Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

Highlights•Structure-based strategies allow more-specific targeting of protein–protein
interactions (PPIs).•Interfering peptides (IPs) become a promising alternative to small …

The p53 tumor suppressor plays a major role in controlling the initiation and development of
cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 …

Ubiquitination is a key enzymatic post-translational modification that influences p53 stability
and function. p53 protein regulates the expression of MDM2 (mouse double-minute 2 …

Potentilla nepalensis belongs to the Rosaceae family and has numerous therapeutic
applications as potent plant-based medicine. Forty phytoconstituents (PCs) from the root and …

Aerobic glycolysis (Warburg effect), a hallmark of cancer, plays a critical role in cancer cell
growth and metastasis; however, direct inhibition of the Warburg effect remains largely …

This review presents the last decade of studies on the synthesis of various types of small-
molecule inhibitors of the p53–Mouse double minute 2 homolog (MDM2) protein–protein …

A hallmark of cancer is dysregulated protein turnover (proteostasis), which involves
pathologic ubiquitin-dependent degradation of tumor suppressor proteins, as well as …