A variety of drug transporters expressed in the body control the fate of drugs by affecting
absorption, distribution, and elimination processes. In the small intestine, transporters …

The interface between luminal contents and intestinal epithelium constitutes the largest area
of interaction between the host and the environment. There is now strong evidence that the …

The MDR1 gene is an attractive candidate gene for the pathogenesis of inflammatory bowel
disease (IBD) and perhaps response to therapy, with evidences at both functional and …

The oral route of drug administration remains the most popular and convenient route of
administration, despite its many shortcomings and challenges. Although the advantages …

Purpose. The aim of this study is to investigate the effects of 50% ethyl acetate extracts of
grapefruit juice (GFJ) and orange juice (OJ) on the transport activity of P-glycoprotein (P-gp) …

The effects of Klebsiella pneumoniae endotoxin on the biliary excretion and renal handling
of rhodamine-123 were investigated in rats at different times after intraperitoneal injection (1 …

The ATP-binding cassette (ABC) family of proteins comprise a group of membrane
transporters involved in the transport of a wide variety of compounds, such as xenobiotics …

Background Inflammatory bowel diseases (IBD) are chronic diseases of unknown etiology
and pathogenesis in which genetic factors contribute to development of disease …