Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

SRY-related high-mobility group box 9 (SOX9) is an indispensable transcription factor that
regulates multiple developmental pathways related to stemness, differentiation, and …

In the later-line setting or for patients with PD-L1-negative tumors, immunotherapy-based
regimens remain ineffective against advanced triple-negative breast cancer (TNBC). In this …

High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here, we
unravel an unanticipated metabolic heterogeneity in HGSOC. By combining proteomic …

Increased cancer stem cell content during development of resistance to tamoxifen in breast
cancer is driven by multiple signals, including Sox2-dependent activation of Wnt signalling …

The promyelocytic leukemia (PML) protein organizes nuclear aggregates known as PML
nuclear bodies (PML-NBs), where many transcription factors localize to be regulated. In …

Membrane-less organelles are condensates formed by phase separation whose functions
often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to …

Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to
regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with …

Arsenic trioxide (ATO) is an effective therapeutic agent against acute promyelocytic
leukemia (APL); however, its anti-tumor effect on solid tumors such as colorectal cancer …

Oncogene addiction postulates that the survival and growth of certain tumor cells is
dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic …