Network science of biological systems at different scales: A review
Network science is today established as a backbone for description of structure and function
of various physical, chemical, biological, technological, and social systems. Here we review …
of various physical, chemical, biological, technological, and social systems. Here we review …
The physiological role of β-cell heterogeneity in pancreatic islet function
RKP Benninger, V Kravets - Nature Reviews Endocrinology, 2022 - nature.com
Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …
transcriptional profile, protein expression and the regulation of hormone release. Even …
Prolactin—a pleiotropic factor in health and disease
The principal role of prolactin in mammals is the regulation of lactation. Prolactin is a
hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary …
hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary …
Beta cell hubs dictate pancreatic islet responses to glucose
NR Johnston, RK Mitchell, E Haythorne, MP Pessoa… - Cell metabolism, 2016 - cell.com
The arrangement of β cells within islets of Langerhans is critical for insulin release through
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …
Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo
Pancreatic β-cells form highly connected networks within isolated islets. Whether this
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …
Pancreatic β-cell identity, glucose sensing and the control of insulin secretion
Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …
PDX1LOW MAFALOW β-cells contribute to islet function and insulin release
Transcriptionally mature and immature β-cells co-exist within the adult islet. How such
diversity contributes to insulin release remains poorly understood. Here we show that subtle …
diversity contributes to insulin release remains poorly understood. Here we show that subtle …
Lipotoxicity disrupts incretin-regulated human β cell connectivity
DJ Hodson, RK Mitchell, EA Bellomo… - The Journal of …, 2013 - Am Soc Clin Investig
Pancreatic β cell dysfunction is pathognomonic of type 2 diabetes mellitus (T2DM) and is
driven by environmental and genetic factors. β cell responses to glucose and to incretins …
driven by environmental and genetic factors. β cell responses to glucose and to incretins …
Patterns of prolactin secretion
HR Phillipps, SH Yip, DR Grattan - Molecular and Cellular Endocrinology, 2020 - Elsevier
Prolactin is pleotropic in nature affecting multiple tissues throughout the body. As a
consequence of the broad range of functions, regulation of anterior pituitary prolactin …
consequence of the broad range of functions, regulation of anterior pituitary prolactin …
What's new in estrogen receptor action in the female reproductive tract
SC Hewitt, W Winuthayanon… - Journal of molecular …, 2016 - jme.bioscientifica.com
Significant progress has been made recently in unravelling the embryonic events leading to
pituitary morphogenesis, both in vivo and in vitro. This includes dissection of the molecular …
pituitary morphogenesis, both in vivo and in vitro. This includes dissection of the molecular …