Network science is today established as a backbone for description of structure and function
of various physical, chemical, biological, technological, and social systems. Here we review …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

The principal role of prolactin in mammals is the regulation of lactation. Prolactin is a
hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary …

The arrangement of β cells within islets of Langerhans is critical for insulin release through
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …

Pancreatic β-cells form highly connected networks within isolated islets. Whether this
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …

Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such
diversity contributes to insulin release remains poorly understood. Here we show that subtle …

Pancreatic β cell dysfunction is pathognomonic of type 2 diabetes mellitus (T2DM) and is
driven by environmental and genetic factors. β cell responses to glucose and to incretins …

Prolactin is pleotropic in nature affecting multiple tissues throughout the body. As a
consequence of the broad range of functions, regulation of anterior pituitary prolactin …

Significant progress has been made recently in unravelling the embryonic events leading to
pituitary morphogenesis, both in vivo and in vitro. This includes dissection of the molecular …