Conotoxins: chemistry and biology

AH Jin, M Muttenthaler, S Dutertre, SWA Himaya… - Chemical …, 2019 - ACS Publications
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …

The pharmacology of voltage-gated sodium channel activators

JR Deuis, A Mueller, MR Israel, I Vetter - Neuropharmacology, 2017 - Elsevier
Toxins and venom components that target voltage-gated sodium (Na V) channels have
evolved numerous times due to the importance of this class of ion channels in the normal …

Dietary breadth is positively correlated with venom complexity in cone snails

MA Phuong, GN Mahardika, ME Alfaro - BMC genomics, 2016 - Springer
Background Although diet is believed to be a major factor underlying the evolution of venom,
few comparative studies examine both venom composition and diet across a radiation of …

The snake with the scorpion's sting: Novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus)

DC Yang, JR Deuis, D Dashevsky, J Dobson… - Toxins, 2016 - mdpi.com
Millions of years of evolution have fine-tuned the ability of venom peptides to rapidly
incapacitate both prey and potential predators. Toxicofera reptiles are characterized by …

Sodium channels and venom peptide pharmacology

MR Israel, B Tay, JR Deuis, I Vetter - Advances in pharmacology, 2017 - Elsevier
Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have
evolved a myriad of components in their venoms that target the opening and/or closing of …

The role of defensive ecological interactions in the evolution of conotoxins

JR Prashanth, S Dutertre, AH Jin, V Lavergne… - Molecular …, 2016 - Wiley Online Library
Venoms comprise of complex mixtures of peptides evolved for predation and defensive
purposes. Remarkably, some carnivorous cone snails can inject two distinct venoms in …

Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snail

A Rogalski, SWA Himaya, RJ Lewis - Nature Communications, 2023 - nature.com
Marine cone snails have attracted researchers from all disciplines but early life stages have
received limited attention due to difficulties accessing or rearing juvenile specimens. Here …

Conotoxin Diversity in Chelyconus ermineus (Born, 1778) and the Convergent Origin of Piscivory in the Atlantic and Indo-Pacific Cones

S Abalde, MJ Tenorio, CML Afonso… - Genome Biology and …, 2018 - academic.oup.com
The transcriptome of the venom duct of the Atlantic piscivorous cone species Chelyconus
ermineus (Born, 1778) was determined. The venom repertoire of this species includes at …

Pharmacological screening technologies for venom peptide discovery

JR Prashanth, N Hasaballah, I Vetter - Neuropharmacology, 2017 - Elsevier
Venomous animals occupy one of the most successful evolutionary niches and occur on
nearly every continent. They deliver venoms via biting and stinging apparatuses with the aim …

Pharmacology of predatory and defensive venom peptides in cone snails

JR Prashanth, S Dutertre, RJ Lewis - Molecular biosystems, 2017 - pubs.rsc.org
Cone snails are predatory gastropods whose neurotoxic venom peptides (conotoxins) have
been extensively studied for pharmacological probes, venom evolution mechanisms and …