The cells of most mammalian organs are connected by groups of cell-to-cell channels called
gap junctions. Gap junction channels are made from the connexin (Cx) family of proteins …

Cataracts (opacities of the lens) are frequent in the elderly, but rare in paediatric practice.
Congenital cataracts (in industrialized countries) are mainly caused by mutations affecting …

The lens is an important determinant of overall vision quality whose refractive and
transparent properties change throughout life. Alterations to the refractive properties of the …

The transparency and refractive properties of the lens are maintained by the cellular
physiology provided by an internal microcirculation system that utilizes spatial differences in …

Aquaporins (AQPs) constitute a major conduit for movement of water across plasma
membranes. AQP0 is expressed in the fiber cells and is critical for lens transparency and …

The pathogenesis of congenital cataract (CC), a major disease associated with blindness in
infants, is complex and diverse. Aquaporin 5 (AQP5) represents an essential membrane …

Aquaporin 0 (AQP0) was originally characterized as a membrane intrinsic protein,
specifically expressed in the lens fibers of the ocular lens and designated MIP, for major …

Purpose: The lens uses circulating fluxes of ions and water that enter the lens at both poles
and exit at the equator to maintain its optical properties. We have mapped the subcellular …

Aquaporins (AQPs), by playing essential roles in the maintenance of ocular lens
homeostasis, contribute to the establishment and maintenance of the overall optical …

Abstract Aquaporin-0 (AQP0), the primary water channel in lens fiber cells, is critical to lens
development, organization, and function. In the avascular lens there is thought to be an …