Biological functions and activities of rice bran as a functional ingredient: A review

S Sapwarobol, W Saphyakhajorn… - Nutrition and metabolic …, 2021 - journals.sagepub.com
Rice bran (RB) is a nutrient-rich by-product of the rice milling process. It consists of pericarp,
seed coat, nucellus, and aleurone layer. RB is a rich source of a protein, fat, dietary fibers …

Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms

H Marei, A Malliri - Small GTPases, 2017 - Taylor & Francis
Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including
cancer, cardiovascular diseases and neurodegenerative disorders. As such, Rac1 …

Oxidatively generated base modifications in DNA: Not only carcinogenic risk factor but also regulatory mark?

M Seifermann, B Epe - Free Radical Biology and Medicine, 2017 - Elsevier
The generation of DNA modifications in cells is in most cases accidental and associated with
detrimental consequences such as increased mutation rates and an elevated risk of …

Aberrant MFN2 transcription facilitates homocysteine‐induced VSMCs proliferation via the increased binding of c‐Myc to DNMT1 in atherosclerosis

L Xu, H Hao, Y Hao, G Wei, G Li, P Ma… - Journal of Cellular …, 2019 - Wiley Online Library
It is well‐established that homocysteine (Hcy) is an independent risk factor for
atherosclerosis. Hcy can promote vascular smooth muscle cell (VSMC) proliferation, it plays …

Markers of oxidative stress in human milk do not differ by maternal BMI but are related to infant growth trajectories

BE Young, ZW Patinkin, L Pyle… - Maternal and child …, 2017 - Springer
Objective Obesity in adults is associated with inflammation and oxidative stress. Whether or
not this phenotype is reflected in human milk (HM) composition, or may impact infant growth …

Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion

C Song, X Zhao - Bioscience reports, 2018 - portlandpress.com
In patients with cerebral infarction (CI), elevated serum uric acid (UA) level may exacerbate
the occurrence and development of carotid atherosclerosis (AS). Our study intended to …

8-Aminopurines in the Cardiovascular and Renal Systems and Beyond

EK Jackson, SP Tofovic, Y Chen, LA Birder - Hypertension, 2023 - Am Heart Assoc
Screening of compounds comprising 8-substituted guanine revealed that 8-aminoguanosine
and 8-aminoguanine cause diuresis/natriuresis/glucosuria, yet decrease potassium …

Exogenous 8-oxo-7, 8-dihydro-2′-deoxyguanosine: biomedical properties, mechanisms of action, and therapeutic potential

AV Chernikov, SV Gudkov, AM Usacheva… - Biochemistry …, 2017 - Springer
Abstract Abstract—8-Oxo-7, 8-dihydroguanine (8-oxo-G) is a key biomarker of oxidative
damage to DNA in cells, and its genotox-icity is well-studied. In recent years, it has been …

An electrochemical aptasensor for the highly sensitive detection of 8-hydroxy-2′-deoxyguanosine based on the hybridization chain reaction

LP Jia, LJ Wang, RN Ma, L Shang, W Zhang, QW Xue… - Talanta, 2018 - Elsevier
In the present work a highly sensitive and selective aptasensor was developed for the
determination of 8-hydroxy-2′-deoxyguanosine (8-OH-dG) based on the hybridization …

Exogenous 8‐hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1‐NADPH oxidase signaling

SK Shin, KO Kim, SH Kim, OS Kwon… - Journal of …, 2020 - Wiley Online Library
Abstract Background and Aim Exogenous 8‐hydroxydeoxyguanosine (8‐OHdG) was
suggested as an inhibitor of Rac1 and NADPH oxidase (NOX). The aim of this study was to …