Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Protein and lipid transport along the endolysosomal system of eukaryotic cells depends on
multiple fusion and fission events. Over the past few years, the molecular constituents of …

Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Membrane fusion is generally controlled by Rabs, soluble N-ethylmaleimide–sensitive factor
attachment protein receptors (SNAREs), and tethering complexes. Syntaxin 17 (STX17) was …

Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …

The mechanisms of endosome biogenesis and maintenance are largely unknown. The
small GTPases Rab5 and Rab7 are key determinants of early and late endosomes …

Autophagic and endocytic pathways are tightly regulated membrane rearrangement
processes that are crucial for homeostasis, development and disease. Autophagic cargo is …

Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …

Melanosomes are tissue-specific lysosome-related organelles of pigment cells in which
melanins are synthesized and stored. Analyses of the trafficking and fate of melanosomal …

The neuronal ceroid lipofuscinoses (NCL) are severe neurodegenerative lysosomal storage
disorders of childhood, characterized by accumulation of autofluorescent ceroid …