Retinoid X receptors (RXRs) present a subgroup of the nuclear receptor superfamily with
particularly high evolutionary conservation of ligand binding domain. The receptor exists in …

Retinoid X receptors (RXRs) control a wide variety of functions by virtue of their dimerization
with other nuclear hormone receptors (NRs), contributing thereby to activities of different …

Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young,
appearing in the fossil record during the Cambrian explosion about 542 to 515 million years …

Nuclear Receptors (NRs) are a superfamily of transcription factors specific to metazoans that
have the unique ability to directly translate the message of a signaling molecule into a …

The placozoan Trichoplax adhaerens is a tiny hairy plate and more simply organized than
any other living metazoan. After its original description by FE Schulze in 1883, it attracted …

Nuclear receptors (NRs) are responsible for the regulation of diverse developmental and
physiological systems in metazoans. NR actions can be the result of genomic and non …

Retinoic acid, the active metabolite of vitamin A, is important for vertebrate cognition and
hippocampal plasticity, but few studies have examined its role in invertebrate learning and …

The challenges around evidence interpretation for the effects of endocrine-disrupting
chemicals (EDCs) on wildlife have been elegantly described in a recent restatement …

Retinoic acid, the active metabolite of Vitamin A, is important for the appropriate
development of the nervous system (eg, neurite outgrowth) as well as for cognition (eg …

Abstract Testicular nuclear receptor 4 (TR4) modulates the transcriptional activation of
genes and plays important roles in many diseases. The regulation of TR4 on target genes …