Cytoskeletal remodeling in cancer

J Aseervatham - Biology, 2020 - mdpi.com
Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

Structure, regulation and related diseases of the actin-binding protein gelsolin

J Feldt, M Schicht, F Garreis, J Welss… - Expert reviews in …, 2018 - cambridge.org
Gelsolin (GSN), one of the most abundant actin-binding proteins, is involved in cell motility,
shape and metabolism. As a member of the GSN superfamily, GSN is a highly structured …

[HTML][HTML] Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3p in non-small cell lung cancer

W Deng, M Yan, T Yu, H Ge, H Lin, J Li, Y Liu… - Cellular Physiology and …, 2015 - karger.com
Background: microRNAs can repress the expression of target genes by destabilizing their
mRNAs or by inhibiting their translation. Our previous findings suggested that miR-193a-3p …

[HTML][HTML] Proteomics and its applications in breast cancer

AN Neagu, D Whitham, E Buonanno… - American journal of …, 2021 - ncbi.nlm.nih.gov
Breast cancer is an individually unique, multi-faceted and chameleonic disease, an eternal
challenge for the new era of high-integrated precision diagnostic and personalized …

Urinary proteome alterations in HER2 enriched breast cancer revealed by multipronged quantitative proteomics

A Gajbhiye, R Dabhi, K Taunk, G Vannuruswamy… - …, 2016 - Wiley Online Library
Globally, breast cancer is the second most common cancer among women. Although
biomarker discoveries through various proteomic approaches of tissue and serum samples …

Metastasis suppressors in breast cancers: mechanistic insights and clinical potential

CR Bohl, S Harihar, WL Denning, R Sharma… - Journal of Molecular …, 2014 - Springer
For the most part, normal epithelial cells do not disseminate to other parts of the body and
proliferate, as do metastatic cells. Presumably, a class of molecules—termed metastasis …

Circulating proteins associated with response and resistance to neoadjuvant chemotherapy in HER2-positive breast cancer

MP Chantada-Vázquez, M Conde-Amboage… - Cancers, 2022 - mdpi.com
Simple Summary The goal of this study was to find circulating proteins that can be easily
sampled and incorporated into a clinical setting to improve predictive treatment response in …

Computational identification of multi-omic correlates of anticancer therapeutic response

LC Stetson, T Pearl, Y Chen, JS Barnholtz-Sloan - BMC genomics, 2014 - Springer
Background A challenge in precision medicine is the transformation of genomic data into
knowledge that can be used to stratify patients into treatment groups based on predicted …

Gelsolin is associated with longer metastasis-free survival and reduced cell migration in estrogen receptor-positive breast cancer

AM Stock, F Klee, K Edlund, M Grinberg… - Anticancer …, 2015 - ar.iiarjournals.org
Background: Tumor cell migration is a prerequisite for metastasis formation. The role of the
actin-modulating protein, gelsolin, in metastasis is controversial, as previous studies have …

Quantitative tissue proteomic investigation of invasive ductal carcinoma of breast with luminal B HER2 positive and HER2 enriched subtypes towards potential …

N Pendharkar, A Gajbhiye, K Taunk… - Journal of …, 2016 - Elsevier
Worldwide, breast cancer is one of the frequently diagnosed cancers in women with high
mortality if not diagnosed at early stage. Although biomarker discoveries through various …