Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …

Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both
genetic and environmental factors. The exact nature of the environmental factors …

Fecal transfer from healthy donors is being explored as a microbiome modality. MicroRNAs
(miRNAs) have been found to affect the microbiome. Multiple sclerosis (MS) patients have …

The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

Background The gut microbiome plays an important role in autoimmunity including multiple
sclerosis and its mouse model called experimental autoimmune encephalomyelitis (EAE) …

Indazoles are a very important class of N‐containing heterocycles with a wide range of
biological and medicinal properties. The presence of different functionalities on indazole …

A major consequence of traumatic brain and spinal cord injury is the loss of the myelin
sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system …

Persistent endoplasmic reticulum (ER) stress in neurons is associated with activation of
inflammatory cells and subsequent neuroinflammation following traumatic brain injury (TBI); …

Objective Accumulating evidence suggests that dysfunctional adipose tissue (AT) plays a
major role in the risk of developing multiple sclerosis (MS), the most common immune …