The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

The world wide prevalence of obesity and the metabolic syndrome is escalating. Contrary to
earlier experimental evidence, human obesity is characterised by sympathetic nervous …

Obesity is a leading cause of death worldwide because of its associated inflammatory
disorders such as hypertension, cardiovascular and kidney diseases, dyslipidemia, glucose …

The renin angiotensin system (RAS; most well-known for its critical roles in the regulation of
cardiovascular function and hydromineral balance) has regained the spotlight for its …

Cachexia is a serious complication of many chronic diseases, such as congestive heart
failure (CHF) and chronic kidney disease (CKD). Many factors are involved in the …

The renin angiotensin system (RAS) is a major regulator of blood pressure, fluid, and
electrolyte homeostasis. RAS precursor angiotensinogen (Agt) is cleaved into angiotensin I …

Maternal-fetal crosstalk has been implicated in long-term control of the health of offspring,
including transgenerational hypertension. However, current knowledge is limited regarding …

Obesity is a risk factor for type 2 diabetes mellitus (DM) and is associated with chronic
kidney disease. Activation of the renin-angiotensin-aldosterone system (RAAS) is common …

The renin-angiotensin-aldosterone system (RAAS) is an enzymatic cascade functioning in a
paracrine and autocrine fashion. In animals and humans, RAAS intrinsic to tissues …