Precision medicine in inflammatory bowel disease: a spotlight on emerging molecular biomarkers

A Mestrovic, N Perkovic, D Bozic, M Kumric… - …, 2024 - pmc.ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBD) remain challenging in terms of understanding their
causes and in terms of diagnosing, treating, and monitoring patients. Modern diagnosis …

The Journey of p38 MAP Kinase Inhibitors: From Bench to Bedside in Treating Inflammatory Diseases

F Yang, LJ Zhao, Q Xu, J Zhao - European Journal of Medicinal Chemistry, 2024 - Elsevier
The p38 mitogen-activated protein kinase (MAPK) pathway is pivotal in regulating
inflammatory responses and has emerged as a key target for the development of small …

An inflammation-related subtype classification for analyzing tumor microenvironment and clinical prognosis in colorectal cancer

J Pei, Y Gao, A Wu - Frontiers in Immunology, 2024 - frontiersin.org
Background The inflammatory response plays an essential role in the tumor
microenvironment (TME) of colorectal cancer (CRC) by modulating tumor growth …

Pharmacological inhibition of receptor-interacting protein kinase 2 (RIPK2) elicits neuroprotective effects following experimental ischemic stroke

J Larochelle, JA Howell, C Yang, L Liu, RE Gunraj… - Experimental …, 2024 - Elsevier
Ischemic stroke induces a debilitating neurological insult, where inflammatory processes
contribute greatly to the expansion and growth of the injury. Receptor-interacting protein …

[HTML][HTML] Resveratrol and p53: How are they involved in CRC plasticity and apoptosis?

A Brockmueller, C Buhrmann… - Journal of Advanced …, 2024 - Elsevier
Background Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle
factors, is very often associated with functional plasticity during its development. In addition …

The role of suppressor of cytokine signaling 3 in inflammatory bowel disease and its associated colorectal cancer

P Zhang, B Pei, C Yi, FA Akanyibah, F Mao - Biochimica et Biophysica Acta …, 2024 - Elsevier
Inflammatory bowel disease (IBD) and colorectal cancer (CRC), as two of the major human
intestinal diseases, provide challenges for the medical field. Suppressor of cytokine …

[HTML][HTML] Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy

F Ruch, J Gnörich, K Wind, M Köhler, A Zatcepin… - NeuroImage, 2024 - Elsevier
Among functional imaging methods, metabolic connectivity (MC) is increasingly used for
investigation of regional network changes to examine the pathophysiology of …

[HTML][HTML] Drosophila: An Important Model for Exploring the Pathways of Inflammatory Bowel Disease (IBD) in the Intestinal Tract

C Zeng, F Liu, Y Huang, Q Liang, X He, L Li… - International Journal of …, 2024 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic and recurring lifelong condition, the exact
etiology of which remains obscure. However, an increasing corpus of research underscores …

[HTML][HTML] Role of epigenetic mechanisms in inflammatory bowel disease

GV Pereira, P Varga-Weisz - Digestive Medicine Research, 2024 - dmr.amegroups.org
Epigenetic mechanisms maintain gene expression states within a cell and through cellular
generations and involve DNA methylation and chromatin changes, such as histone …

The use of resveratrol in the fight against Cancer in women: a review

CC Andreato, A Kulpe… - Brazilian Journal of …, 2024 - ojs.brazilianjournals.com.br
Cancer continues to be a major global health challenge, especially among women. Recent
scientific studies have focused on resveratrol (RSV), a natural polyphenol found in various …