The programmed cell death that occurs as part of normal mammalian development was first
observed nearly a century ago (Collin 1906). It has since been established that …

Interactions between the immune system and malignant cells play an important role in
tumorigenesis. Failure of the immune system to detect and reject transformed cells may lead …

A single-nucleotide polymorphism (SNP), identified at nucleotide position− 844 in the 5′
promoter of the FasL gene, lies within a putative binding motif for CAAT/enhancer-binding …

Lymphocytes of the adaptive immune system play a crucial role in defending the organism
against pathogens. Initial stimulation via antigen receptors induces activation and …

The critical function of NFAT proteins in maintaining lymphoid homeostasis was revealed in
mice lacking both NFATp and NFAT4 (DKO). DKO mice exhibit increased …

CD95/CD95L mediated apoptosis is an important mechanism of immune homeostasis. It is
instrumental for termination of an immune response and mainly be involved in peripheral …

Efficient activation of antigen‐specific T cells requires co‐stimulatory signals provided eg by
CD28. Re‐exposure to antigen and CD28 co‐stimulation reduces activation‐induced cell …

Activation-induced cell death (AICD), which results from the interaction between Fas and
Fas ligand, is responsible for maintaining tolerance to self-antigen. A defect in AICD may …

The CD95 (also called APO-1 or Fas) system plays a major role in the induction of apoptosis
in lymphoid and nonlymphoid tissues in response to a variety of extracellular signals …

CD3-negative NK cells are granular lymphocytes capable of producing inflammatory
cytokines and killing malignant, infected, or stressed cells. We have recently observed a new …