With the emergence of individualized medicine and the increasing amount and complexity of
available medical data, a growing need exists for the development of clinical decision …

Radiobiological research over the past decades has provided evidence that cancer stem
cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours …

Dose painting is the prescription of a nonuniform radiation dose distribution to the target
volume based on functional or molecular images shown to indicate the local risk of relapse …

PURPOSE: Development of a radiosensitivity predictive assay is a central goal of radiation
oncology. We reasoned a gene expression model could be developed to predict intrinsic …

Activation of the phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is
associated with three major radioresistance mechanisms: intrinsic radioresistance; tumour …

In this treatise oral carcinogenesis is briefly discussed, particularly with regard to the number
of cell divisions that is required before cancer reaches a measurable size. At that stage …

A paradigm shift from current population based medicine to personalized and participative
medicine is underway. This transition is being supported by the development of clinical …

Background and purpose: Tumor oxygenation is recognized as an important determinant of
the outcome of radiotherapy and possibly also of other treatment modalities in a number of …

Two mechanisms of radiotherapy resistance which are of major importance in various
tumour types are tumour-cell repopulation and hypoxia. ARCON (accelerated radiotherapy …

Managing the new product development (NPD) is a challenging mission, and most
researches would argue that design is fundamentally linked to intentional action and it …