Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling
Particle design via spherical agglomeration is a size enlargement technique used in various
bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in …
bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in …
Morphological characterization of aggregates and agglomerates by image analysis: A systematic literature review
L Théodon, J Debayle, C Coufort-Saudejaud - Powder Technology, 2023 - Elsevier
The morphological characterization of aggregates or agglomerates using image analysis is
an increasingly active area of research, whether in the chemical, environmental or civil …
an increasingly active area of research, whether in the chemical, environmental or civil …
Tuning the particle sizes in spherical agglomeration
This paper presents an experimental technique for tuning the size of spherical agglomerates
together with a simple model that provides qualitative information on the agglomerate size …
together with a simple model that provides qualitative information on the agglomerate size …
Modeling and optimization of spherical agglomeration in suspension through a coupled population balance model
The population balance model is the common approach to simulation and prediction of the
size distribution and other properties of particulate systems. Population balance models …
size distribution and other properties of particulate systems. Population balance models …
Revealing Crystal Aggregates' Evolution through In Situ Visualization in Cooling Crystallization
The transition process and control mechanisms of crystal aggregates to agglomerates hold
significant importance in reducing subsequent processing steps and enhancing crystal …
significant importance in reducing subsequent processing steps and enhancing crystal …
Particle engineering of benzoic acid by spherical agglomeration
J Thati, ÅC Rasmuson - European journal of pharmaceutical sciences, 2012 - Elsevier
The influence of process conditions on the properties of benzoic acid spherical
agglomerates, are investigated. Agglomerates are produced in a fed-batch agitated tank …
agglomerates, are investigated. Agglomerates are produced in a fed-batch agitated tank …
Iterative model‐based experimental design for spherical agglomeration processes
Spherical agglomeration (SA) is a process intensification strategy, which can reduce the
number of unit operations in pharmaceutical manufacturing. SA merges drug substance …
number of unit operations in pharmaceutical manufacturing. SA merges drug substance …
Mechanistic modelling of spherical agglomeration processes
Spherical agglomeration is emerging as an important unit process for pharmaceutical
manufacturing. However, at present, quantitative process design to control agglomerate …
manufacturing. However, at present, quantitative process design to control agglomerate …
High-shear granulation: An investigation into the granule consolidation and layering mechanism
SAL de Koster, K Pitt, JD Litster, RM Smith - Powder Technology, 2019 - Elsevier
The mechanisms of early granule growth are difficult to study and poorly understood.
Consolidation and layering play a critical role in the growth process. However, little is known …
Consolidation and layering play a critical role in the growth process. However, little is known …
Agglomeration in suspension of salicylic acid fine particles: Analysis of the wetting period and effect of the binder injection mode on the final agglomerate size
C Subero-Couroyer, D Mangin, A Rivoire, AF Blandin… - Powder technology, 2006 - Elsevier
Agglomeration in suspension is a size enlargement method which facilitates the operations
of solid processing such as filtration, transport and galenic while preserving the …
of solid processing such as filtration, transport and galenic while preserving the …