Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling

K Pitt, R Peña, JD Tew, K Pal, R Smith, ZK Nagy… - Powder Technology, 2018 - Elsevier
Particle design via spherical agglomeration is a size enlargement technique used in various
bulk and fine chemical industries, with recent interest extending into pharmaceuticals, in …

Morphological characterization of aggregates and agglomerates by image analysis: A systematic literature review

L Théodon, J Debayle, C Coufort-Saudejaud - Powder Technology, 2023 - Elsevier
The morphological characterization of aggregates or agglomerates using image analysis is
an increasingly active area of research, whether in the chemical, environmental or civil …

Tuning the particle sizes in spherical agglomeration

PM Orlewski, B Ahn, M Mazzotti - Crystal Growth & Design, 2018 - ACS Publications
This paper presents an experimental technique for tuning the size of spherical agglomerates
together with a simple model that provides qualitative information on the agglomerate size …

Modeling and optimization of spherical agglomeration in suspension through a coupled population balance model

R Peña, CL Burcham, DJ Jarmer, D Ramkrishna… - Chemical Engineering …, 2017 - Elsevier
The population balance model is the common approach to simulation and prediction of the
size distribution and other properties of particulate systems. Population balance models …

Revealing Crystal Aggregates' Evolution through In Situ Visualization in Cooling Crystallization

Y Xiao, Z Pan, H Wang, T Li, B Kong - Industrial & Engineering …, 2024 - ACS Publications
The transition process and control mechanisms of crystal aggregates to agglomerates hold
significant importance in reducing subsequent processing steps and enhancing crystal …

Particle engineering of benzoic acid by spherical agglomeration

J Thati, ÅC Rasmuson - European journal of pharmaceutical sciences, 2012 - Elsevier
The influence of process conditions on the properties of benzoic acid spherical
agglomerates, are investigated. Agglomerates are produced in a fed-batch agitated tank …

Iterative model‐based experimental design for spherical agglomeration processes

K Pal, B Szilagyi, CL Burcham, DJ Jarmer… - AIChE …, 2021 - Wiley Online Library
Spherical agglomeration (SA) is a process intensification strategy, which can reduce the
number of unit operations in pharmaceutical manufacturing. SA merges drug substance …

Mechanistic modelling of spherical agglomeration processes

B Ahmed, O Arjmandi-Tash, JD Litster, RM Smith - Powder Technology, 2023 - Elsevier
Spherical agglomeration is emerging as an important unit process for pharmaceutical
manufacturing. However, at present, quantitative process design to control agglomerate …

High-shear granulation: An investigation into the granule consolidation and layering mechanism

SAL de Koster, K Pitt, JD Litster, RM Smith - Powder Technology, 2019 - Elsevier
The mechanisms of early granule growth are difficult to study and poorly understood.
Consolidation and layering play a critical role in the growth process. However, little is known …

Agglomeration in suspension of salicylic acid fine particles: Analysis of the wetting period and effect of the binder injection mode on the final agglomerate size

C Subero-Couroyer, D Mangin, A Rivoire, AF Blandin… - Powder technology, 2006 - Elsevier
Agglomeration in suspension is a size enlargement method which facilitates the operations
of solid processing such as filtration, transport and galenic while preserving the …