Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability
worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Background Inflammatory responses play a multiphase role in the pathogenesis of cerebral
ischemic stroke (IS). Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces …

Following a cerebral ischemic event, substantial alterations in both cellular and molecular
activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates …

Accurate and dynamic visualization of vascular diseases can contribute to restraining further
deterioration from diseases in a timely manner. However, visualization is still unable to …

Stroke remains the leading cause of long-term disability worldwide with significant long-term
sequelae. However, there is no highly effective treatment to enhance post-stroke recovery …

CC motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein
family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate …

Ischaemic disorders are leading causes of morbidity and mortality worldwide. While the
current therapeutic approaches have improved life expectancy and quality of life, they are …

Ischemic stroke (IS) is a cerebrovascular disease causing high rates of disability and fatality.
In recent years, the concept of the neurovascular unit (NVU) has been accepted by an …

In ischemic retinopathy, overactivated retinal myeloid cells are a crucial driving force of
pathological angiogenesis and inflammation. The cyclic GMP-AMP synthase (cGAS) and …