Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …

Hyperpolarized (HP) carbon 13 (13C) MRI is an emerging molecular imaging method that
allows rapid, noninvasive, and pathway-specific investigation of dynamic metabolic and …

Summary Protein-restricted (PR), high-carbohydrate diets improve metabolic health in
rodents, yet the precise dietary components that are responsible for these effects have not …

Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to
nitrogen-15 in pyridine and nicotinamide (vitamin B3 amide) by conducting “signal …

Ketone bodies are metabolized through evolutionarily conserved pathways that support
bioenergetic homeostasis, particularly in brain, heart, and skeletal muscle when …

The study of transient chemical phenomena by conventional NMR has proved elusive,
particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear …

Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last
century, our knowledge of metabolic pathway architecture and the genomic landscape of …

Gluconeogenesis is critical for maintenance of euglycemia during fasting. Elevated
gluconeogenesis during type 2 diabetes (T2D) contributes to chronic hyperglycemia …

Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …