Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality
worldwide and seriously threatens human health and life. Cardiomyocyte death is …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

Cancer progression including proliferation, metastasis, and chemoresistance has become a
serious hindrance to cancer therapy. This phenomenon mainly derives from the innate …

Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic
and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can …

As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and
lipid peroxide accumulation, which is different from other regulated cell death forms …

Primary liver cancer is among the most common fatal solid cancers, ranking as the fourth
most frequent cause of cancer-related mortality worldwide. Hepatocellular carcinoma (HCC) …

Idiosyncratic drug‐induced liver injury (IDILI) is a significant source of drug recall and acute
liver failure (ALF) in the United States. While current drug development processes …

Dioscin showed various pharmacological effects in our previous studies; however, the
effects and mechanisms against lung ischemia/reperfusion injury (LI/RI) have not been …

Introduction: Nuclear factor (erythroid-derived-2)-like 2 is one of the most efficient
cytoprotective rheostats against exogenous or endogenous oxidative insults. At present, the …

Background: The triad of drug efficacy, toxicity and resistance underpins the risk-benefit
balance of all therapeutics. The application of pharmacogenomics has the potential to …