Patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) usually present
bilateral benign adrenocortical macronodules at imaging and variable levels of cortisol …

Importance Cushing syndrome is defined as a prolonged increase in plasma cortisol levels
that is not due to a physiological etiology. Although the most frequent cause of Cushing …

In patients with Cushing's disease (CD), prompt diagnosis and treatment are essential for
favorable long-term outcomes, although this remains a challenging task. The differential …

Objective To evaluate diagnostic accuracy of the corticotropin-releasing hormone (CRH)
stimulation test and the overnight 8 mg dexamethasone suppression test (DST) for the …

Background Cushing syndrome is characterized by glucocorticoid excess, which induces
physical and mental symptoms, impairments in functional status and perceived health …

Summary Objective Hypercortisolism in Cushing's syndrome (CS) is associated with
impaired health‐related quality of life (HRQ oL), which may persist despite remission. We …

Context The human corticotropin-releasing hormone (CRH) test (hCRHtest) is used to
differentiate Cushing disease (CD) from ectopic adrenocorticotropin (ACTH) secretion …

There is continuous and growing interest in research into new alternatives to standard
biomarkers to detect and follow-up disease, reducing physical and psychological stress in …

Abstract This phase 2, single-arm, open-label, dose-titration, multicenter study evaluated
osilodrostat (11β-hydroxylase inhibitor) in Japanese patients with endogenous Cushing's …

Background Surgery is the definitive treatment of Cushing's syndrome (CS) but medications
may also be used as a first-line therapy. Whether preoperative medical treatment (PMT) …