The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2
(KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis …

The search for new and effective treatment targets for cancer immunotherapy is an ongoing
challenge. Alongside the more established inhibitory immune checkpoints, a novel potential …

Background CD73 upregulation in tumors leads to local immunosuppression. This phase I,
first-in-human study evaluated oleclumab (MEDI9447), an anti-CD73 human IgG1λ …

Background Intrinsic or acquired resistance to epidermal growth factor receptor-tyrosine
kinase inhibitors (EGFR-TKIs) is common, thus strategies for the management of EGFR-TKIs …

Adenosine is an endogenous nucleoside that regulates many physiological and
pathological processes. It is derived from either the intracellular or extracellular …

Tumors, a disease with a high mortality rate worldwide, have become a serious threat to
human health. Exonucleotide-5′-nucleotidase (CD73) is an emerging target for tumor …

As small non-coding RNAs, MicroRNAs (miRNAs) bind to the 3′ untranslated region (3′-
UTR) of mRNA targets to control gene transcription and translation. The gene of miR-330 …

Simple Summary It is a long-held notion that loss-of-function mutations in negative
regulators of the Hippo-YAP pathway, such as NF2, LATS1/2, have a similar potential to …

CD73 is the key enzyme in the generation of extracellular adenosine, a mediator involved in
tumor progression, tumor immune escape and resistance to anti-cancer therapeutics …

Simple Summary The systemic treatment of advanced sarcoma remains challenging.
Conventional chemotherapy and anti-angiogenic agents, even in the most responsive …