Proteomes are complex—much more so than genomes or transcriptomes. Thus, simplifying
their analysis does not simplify the issue. Proteomes are of proteoforms, not canonical …

The Trans-Proteomic Pipeline (TPP) mass spectrometry data analysis suite has been in
continual development and refinement since its first tools, PeptideProphet and …

Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …

Insects, unlike vertebrates, are widely believed to lack male-biased sex steroid hormones. In
the malaria mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) …

Proteomics is the large scale study of protein structure and function from biological systems
through protein identification and quantification.“Shotgun proteomics” or “bottom-up …

Background In proteomics, the interpretation of mass spectra representing peptides carrying
multiple complex modifications remains challenging, as it is difficult to strike a balance …

High-field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to liquid
chromatography-mass spectrometry (LC-MS) has been shown to increase peptide and …

Mass spectrometry (MS) is an analytical technique for molecule identification that can be
used for investigating protein-metal complex interactions. Once the MS data is collected, the …

A thorough evaluation of the quality, reproducibility, and variability of bottom-up proteomics
data is necessary at every stage of a workflow from planning to analysis. We share real …

Centrosomes are the principal microtubule-organizing centers of the cell and play an
essential role in mitotic spindle function. Centrosome biogenesis is achieved by strict control …