Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic
signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors …

New Findings• What is the topic of this review? This is a personal historical review about the
discovery and the main conceptual advances leading to our current understanding of …

Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5′-
triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves …

Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection
and neuroregeneration. Initially there is a brief summary of the background of purinergic …

Abstract Adenosine 5′‐triphosphate (ATP) was identified in 1970 as the transmitter
responsible for non‐adrenergic, non‐cholinergic neurotransmission in the gut and bladder …

Psychiatric disorders are debilitating diseases, affecting> 80 million people worldwide.
There are no causal cures for psychiatric disorders and available therapies only treat the …

In this study, we examined the Ca2+-permeable Piezo1 channel, a newly identified
mechanosensing ion channel, in human dental pulp-derived mesenchymal stem cells …

At high levels, extracellular ATP operates as a “danger” molecule under pathologic
conditions through purinergic receptors, including the ionotropic P2X7 receptor (P2X7R). Its …

S-Nitrosylation is a post-translational modification on cysteine (s) that can regulate protein
function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in …

Abstract Purpose of Review To summarize and discuss recent progress and novel signaling
mechanisms relevant to bone marrow adipocyte formation and its physiological …