Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

Postpartum psychiatric disorders

S Meltzer-Brody, LM Howard, V Bergink… - Nature Reviews …, 2018 - nature.com
Pregnancy is a complex and vulnerable period that presents a number of challenges to
women, including the development of postpartum psychiatric disorders (PPDs). These …

Association between maternal depression and maternal sensitivity from birth to 12 months: A meta-analysis

K Bernard, G Nissim, S Vaccaro, JL Harris… - Attachment & human …, 2018 - Taylor & Francis
Maternal sensitivity plays a central role in shaping children's development across a number
of domains, and may be disrupted by depression. The current meta-analysis quantified the …

Oxytocin and postpartum depression: A systematic review

TA Thul, EJ Corwin, NS Carlson, PA Brennan… - …, 2020 - Elsevier
Postpartum depression (PPD) is a significant mental health concern, especially for women in
vulnerable populations. Oxytocin (OT), a hormone essential for a variety of maternal tasks …

Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children

DS Carson, SW Berquist, TH Trujillo, JP Garner… - Molecular …, 2015 - nature.com
The neuropeptide oxytocin (OXT) exerts anxiolytic and prosocial effects in the central
nervous system of rodents. A number of recent studies have attempted to translate these …

Developmental programming of oxytocin through variation in early-life stress: Four meta-analyses and a theoretical reinterpretation

BJ Ellis, AJ Horn, CS Carter, MH van IJzendoorn… - Clinical Psychology …, 2021 - Elsevier
Despite evidence supporting a role for oxytocin (OT) in regulating social behavior,
surprisingly little is known about how this neuropeptide is calibrated during development …

Oxytocin and HPA stress axis reactivity in postpartum women

EQ Cox, A Stuebe, B Pearson, K Grewen… - …, 2015 - Elsevier
Background Lactation is thought to buffer stress reactivity via oxytocin (OT). Dysregulation of
the HPA axis has been reported in women with postpartum depression (PPD). The co …

Association of peripartum synthetic oxytocin administration and depressive and anxiety disorders within the first postpartum year

AR Kroll‐Desrosiers, BC Nephew… - Depression and …, 2017 - Wiley Online Library
Background Due to its potent effects on social behavior, including maternal behavior,
oxytocin has been identified as a potential mediator of postpartum depression and anxiety …

Oxytocin: at birth and beyond. A systematic review of the long‐term effects of peripartum oxytocin

DT Monks, A Palanisamy - Anaesthesia, 2021 - Wiley Online Library
Oxytocin is one of the most commonly used medications during labour and delivery. Recent
insights from basic neuroscience research suggest that the uterotonic effects of oxytocin may …

A unified model of the biology of peripartum depression

G Levin, T Ein-Dor - Translational Psychiatry, 2023 - nature.com
Peripartum depression (PPD) is a prevalent and debilitating disorder that adversely affects
the development of mothers and infants. Recently, there has been a plea for increased …