History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

Mitochondria and mitochondrial cascades in Alzheimer's disease

RH Swerdlow - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

Building better biomarkers: brain models in translational neuroimaging

CW Woo, LJ Chang, MA Lindquist, TD Wager - Nature neuroscience, 2017 - nature.com
Despite its great promise, neuroimaging has yet to substantially impact clinical practice and
public health. However, a developing synergy between emerging analysis techniques and …

The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer's disease and Parkinson's disease

G Monzio Compagnoni, A Di Fonzo, S Corti… - Molecular …, 2020 - Springer
Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

[HTML][HTML] Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies

Z Chen, C Zhong - Progress in neurobiology, 2013 - Elsevier
Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which
severely impacts on the global economic development and healthcare system. Though AD …

Dysfunctional mitochondria and mitophagy as drivers of Alzheimer's disease pathogenesis

A Chakravorty, CT Jetto, R Manjithaya - Frontiers in aging …, 2019 - frontiersin.org
Neurons are highly specialized post-mitotic cells that are inherently dependent on
mitochondria owing to their high bioenergetic demand. Mitochondrial dysfunction is …

Neuroimaging biomarkers for Alzheimer's disease

F Márquez, MA Yassa - Molecular neurodegeneration, 2019 - Springer
Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …

An application of prefrontal cortex function theory to cognitive aging.

RL West - Psychological bulletin, 1996 - psycnet.apa.org
The purpose of this review is to extend the existing application of the frontal lobe hypothesis
of cognitive aging beyond the limited work on inhibitory control (FN Dempster, 1992) to …

A systematic review of glucose transport alterations in Alzheimer's disease

N Kyrtata, HCA Emsley, O Sparasci… - Frontiers in …, 2021 - frontiersin.org
Introduction: Alzheimer's disease (AD) is characterized by cerebral glucose
hypometabolism. Hypometabolism may be partly due to reduced glucose transport at the …

Estrogen actions in the central nervous system

BS McEwen, SE Alves - Endocrine reviews, 1999 - academic.oup.com
Estrogen Actions in the Central Nervous System* | Endocrine Reviews | Oxford Academic
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