Abstract Development of the nervous system is carried out by complex gene expression
programs that are regulated at both transcriptional and translational level. In addition, quality …

Nucleoli, the sites of ribosome biogenesis, form around ribosomal gene (rDNA) arrays
termed nucleolar organiser regions (NORs). These are the most transcriptionally active …

In the yeast Saccharomyces cerevisiae, genomic instability in rDNA repeat sequences is an
underlying cause of cell aging and is suppressed by the chromatin-silencing factor Sir2. In …

Big data analytics is a very fast growing research domain which embedded the combination
of computational (ie computer-intensive) and inferential (ie statisticsoriented) thinking …

RNA–DNA hybrids are epigenetic features of all genomes that intersect with many
processes, including transcription, telomere homeostasis, and centromere function …

Cells from Bloom's syndrome patients display genome instability due to a defective BLM and
the downregulation of cytidine deaminase. Here, we use a genome-wide RNAi-synthetic …

The ribosomal DNA (rDNA) in Drosophila is found as two additive clusters of individual 35 S
cistrons. The multiplicity of rDNA is essential to assure proper translational demands, but the …

The regulation of gene expression has been studied for decades, but the underlying
mechanisms are still not fully understood. As well as local and distant regulation, there are …

Although recurrent cancers can become life threatening, little is known about the
intracellular events required for cancer recurrences. Due to this lack of mechanistic …

Simple Summary There are nine DSB hot spots located in the non-transcribed spacer of
human rDNA units. Circular chromosome conformation capture data indicate that the rDNA …