Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …

Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …

Nanoparticle-based mRNA therapeutics hold great promise, but cellular internalization and
endosomal escape remain key barriers for cytosolic delivery. We developed a dual …

Conspectus Over the past decades, major efforts were undertaken to develop devices on a
nanoscale level for the efficient and nontoxic delivery of molecules to tissues and cells, for …

The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …

With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

Nanomedical research necessarily involves the study of the interactions between
nanoparticulates and the biological environment. Transmission electron microscopy has …

The modification of targeting ligands on nanoparticles (NPs) is anticipated to enhance the
delivery of therapeutics to diseased tissues. However, once exposed to the blood stream …

Upon entering the biological milieu, nanomedicines swiftly interact with the surrounding
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …