The role of inflammation in autoimmune disease: a therapeutic target
Y Xiang, M Zhang, D Jiang, Q Su, J Shi - Frontiers in Immunology, 2023 - frontiersin.org
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are
increasing year by year. AIDs are produced by the immune system's misidentification of self …
increasing year by year. AIDs are produced by the immune system's misidentification of self …
Interleukin-6: molecule in the intersection of cancer, ageing and COVID-19
Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the
initiation of the immune response. The increased level of this cytokine in the elderly seems …
initiation of the immune response. The increased level of this cytokine in the elderly seems …
The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation
Y Pan, Y You, L Sun, Q Sui, L Liu… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Psoriasis is a chronic inflammatory skin disease associated with
both innate and adaptive immune responses. The stimulator of interferon genes (STING) …
both innate and adaptive immune responses. The stimulator of interferon genes (STING) …
Leveraging decagonal in-silico strategies for uncovering IL-6 inhibitors with precision
AK Swaroop, PKK Namboori… - Computers in Biology …, 2023 - Elsevier
Interleukin-6 upregulation leads to various acute phase reactions such as local inflammation
and systemic inflammation in many diseases like cancer, multiple sclerosis, rheumatoid …
and systemic inflammation in many diseases like cancer, multiple sclerosis, rheumatoid …
Nature vs. nurture: FOXP3, genetics, and tissue environment shape Treg function
A Raugh, D Allard, M Bettini - Frontiers in Immunology, 2022 - frontiersin.org
The importance of regulatory T cells (Tregs) in preventing autoimmunity has been well
established; however, the precise alterations in Treg function in autoimmune individuals and …
established; however, the precise alterations in Treg function in autoimmune individuals and …
Role of interleukin-17 in acute pancreatitis
G Li, H Chen, L Liu, P Xiao, Y Xie, X Geng… - Frontiers in …, 2021 - frontiersin.org
Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by
systemic manifestations that are generally associated with a poor prognosis. Many cytokines …
systemic manifestations that are generally associated with a poor prognosis. Many cytokines …
Neuron-specific vitamin D signaling attenuates microglia activation and CNS autoimmunity
PW Lee, A Selhorst, SG Lampe, Y Liu, Y Yang… - Frontiers in …, 2020 - frontiersin.org
Low vitamin D during childhood is associated with an increased risk of developing multiple
sclerosis (MS) as an adult. Given that vitamin D has anti-inflammatory properties, it has been …
sclerosis (MS) as an adult. Given that vitamin D has anti-inflammatory properties, it has been …
Ironing Out the Mechanism of gp130 Signaling
EEA Osman, N Neamati - Pharmacological Reviews, 2024 - pharmrev.aspetjournals.org
gp130 functions as a shared signal-transducing subunit not only for interleukin (IL)-6 but
also for eight other human cytokine receptor complexes. The IL-6 signaling pathway …
also for eight other human cytokine receptor complexes. The IL-6 signaling pathway …
Navigating IL-6: From molecular mechanisms to therapeutic breakthroughs
This concise review navigates the intricate realm of Interleukin-6 (IL-6), an important
member of the cytokine family. Beginning with an introduction to cytokines, this narrative …
member of the cytokine family. Beginning with an introduction to cytokines, this narrative …
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine …
XL Jie, ZR Luo, J Yu, ZR Tong, QQ Li, JH Wu… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Pi-Pa-Run-Fei-Tang (PPRFT) is an empirical
TCM prescription for treating asthma. However, the underlying mechanisms of PPRFT in …
TCM prescription for treating asthma. However, the underlying mechanisms of PPRFT in …