Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

Impaired apoptosis plays a central role in cancer development and limits the efficacy of
conventional cytotoxic therapies. Deepening understanding of how opposing factions of the …

Chemotherapy is one of the prevailing methods used to treat malignant tumours, but the
outcome and prognosis of tumour patients are not optimistic. Cancer cells gradually …

Intrinsic apoptosis, the response to intracellular cell death stimuli, is regulated by the
interplay of the B-cell lymphoma 2 (Bcl-2) family and their membrane interactions. Bcl-2 …

Dysregulation of the mitochondrial apoptotic pathway controlled by members of the Bcl-2
protein family plays a central role in cancer development and resistance to conventional …

Humanin (HN) is a small mitochondrial-derived cytoprotective polypeptide encoded by
mtDNA. HN exhibits protective effects in several cell types, including leukocytes, germ cells …

Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain
serious threats to public health because of the shortage of effective means of control. To …

Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by
self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables were …

Mutations that impair apoptosis contribute to cancer development and reduce the
effectiveness of conventional anti-cancer therapies. These insights and understanding of …

Members of the B cell lymphoma-2 (Bcl-2) family are pivotal arbiters of mitochondrially
mediated apoptosis, a process of fundamental importance during tissue development …