▪ Abstract Most prokaryotic signal-transduction systems and a few eukaryotic pathways use
phosphotransfer schemes involving two conserved components, a histidine protein kinase …

Two-component signal transduction based on phosphotransfer from a histidine protein
kinase to a response regulator protein is a prevalent strategy for coupling environmental …

Phosphotransfer-mediated signaling pathways allow cells to sense and respond to
environmental stimuli. Autophosphorylating histidine protein kinases provide phosphoryl …

Posttranslational modification by phosphorylation is a ubiquitous regulatory mechanism in
both eukaryotes and prokaryotes. Intracellular phosphorylation by protein kinases, triggered …

CheY-like phosphoacceptor (or receiver [REC]) domain is a common module in a variety of
response regulators of the bacterial signal transduction systems. In this work, 4,610 …

We present a comprehensive overview of the hierarchical network of intracellular processes
revolving around central nitrogen metabolism in Escherichia coli. The hierarchy intertwines …

Protein actions are usually discussed in terms of static structures, but function requires
motion. We find a strong correlation between phosphorylation-driven activation of the …

It is well-established that dynamics are central to protein function; their importance is
implicitly acknowledged in the principles of the Monod, Wyman and Changeux model of …

Cytokinins are plant hormones implicated in diverse and essential processes in plant growth
and development, and key genes for the metabolism and actions of cytokinins have recently …

An approach to find transition pathways in complex systems is presented. The method,
which is related to the string method in collective variables of Maragliano et al.(J. Chem …